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Squamous cell carcinoma of head and neck
1 OMIM reference -
4 associated genes
No signs/symptoms info
PROTEIN INTERACTIONS: 1
Generalized epidermolysis bullosa simplex, non-Dowling-Meara type
1 OMIM reference -
2 associated genes
17 signs/symptoms
Squamous cell carcinoma of head and neck
Generalized epidermolysis bullosa simplex, non-Dowling-Meara type

ING1
(UniProt - OMIM)
 KRT14
(UniProt - OMIM)
ING3
(UniProt - OMIM)
 KRT5
(UniProt - OMIM)
PTEN
(UniProt - OMIM)
TNFRSF10B
(UniProt - OMIM)

INTERACTOME
ASSOCIATIONS
(click on a score value to see the evidence)
PTEN
(0.63)
KRT14


Citations in the biomedical literature:


Squamous cell carcinoma of head and neck
ING1 ING3 PTEN TNFRSF10B
Generalized epidermolysis bullosa simplex, non-Dowling-Meara type
KRT14 KRT5



Squamous cell carcinoma of head and neck
Generalized epidermolysis bullosa simplex, non-Dowling-Meara type

Synonym(s):
- HNSCC
- Head and neck squamous cell carcinoma
Synonym(s):
- Epidermolysis bullosa simplex, Koebner type
- Epidermolysis bullosa simplex, Köbner type
- Generalized EBS, non-Dowling-Meara type
Classification (Orphanet):
- Rare oncologic disease
Classification (Orphanet):
- Rare genetic disease
- Rare skin disease
Classification (ICD10):
(no data available)
Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -
Epidemiological data:
(no data available)
Epidemiological data:
Class of prevalence: unknown
Average age onset: neonatal/infancy
Average age of death: normal
Type of inheritance: autosomal dominant
External references:
1 OMIM reference -
1 MeSH reference: C535575
External references:
1 OMIM reference -
1 MeSH reference: C535961
Generalized epidermolysis bullosa simplex, non-Dowling-Meara type

Very frequent
- Autosomal recessive inheritance
- Enanthema / aphtosa / aphta / leukoplakia
- Mucosal / cutaneous hemorrhage
- Muscle weakness / flaccidity
- Vesicles / bullous / exsudative lesions / bullous / cutaneous / mucosal detachment

Frequent
- Enamel anomaly
- Follicular / erythematous / edematous papules / milium
- Hyperhidrosis / increased sweating
- Hyperkeratosis / ainhum / hyperkeratotic skin fissures
- Nails anomalies
- Ophthalmoplegia / ophthalmoparesis / oculomotor palsy
- Palmoplantar hyperkeratosis / keratoderma
- Ptosis
- Respiratory rhythm disorder

Occasional
- Failure to thrive / difficulties for feeding in infancy / growth delay
- Myasthenia
- Respiratory distress / dyspnea / respiratory failure / lung volume reduction


Squamous cell carcinoma of head and neck

(no data available)